Journal article
Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium
AN Minlikeeva, R Cannioto, A Jensen, SK Kjaer, SJ Jordan, B Diergaarde, JB Szender, K Odunsi, H Almohanna, P Mayor, K Starbuck, E Zsiros, EV Bandera, DW Cramer, JA Doherty, A Defazio, R Edwards, EL Goode, MT Goodman, E Hogdall Show all
Cancer Causes and Control | SPRINGER | Published : 2019
Abstract
Purpose Previous epidemiologic studies have shown that smoking, obesity, and physical inactivity are associated with poor survival following a diagnosis of ovarian cancer. Yet, the combined relationship of these unfavorable lifestyle factors on ovarian cancer survival has not been sufficiently investigated. Methods Using data pooled from 13 studies, we examined the associations between combined exposures to smoking, over-weight/obesity weight, and physical inactivity and overall survival (OS) as well as progression-free survival (PFS) among women diagnosed with invasive epithelial ovarian carcinoma (n = 7,022). Using age-and stage-adjusted Cox proportional hazards regression models, we e..
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Awarded by Mayo Foundation for Medical Education and Research
Funding Acknowledgements
A.N. Minlikeeva was supported by National Cancer Institute (NCI) NIH/NCI 4R25CA113951 and NIH/NCI P50CA159981; K.B. Moysich was supported by NIH/NCI (2R25CA113951, R01CA095023, R01CA126841, P50CA159981) and the Roswell Park Alliance Foundation; K. Odunsi was supported by the Roswell Park Alliance Foundation and NIH/NCI P50CA159981; J.B. Szender, K. Starbuck, and P.C. Mayor were supported by the NIH T32 training grant T32CA108456; S.J. Jordan was supported by National Health & Medical Research Council of Australia NHMRC APP1061341, C.M. Nagle by NHMRC APP1073898, and PM Webb by NHMRC APP1043134; AUS was supported by U.S. Army Medical Research and Materiel Command (DAMD17-01-1-0729), NHMRC (199600 and 400281), Cancer Councils of New South Wales, Victoria, Queensland, South Australia and Tasmania, and the Cancer Foundation of Western Australia; CON was supported by NIH (R01-CA074850 and R01-CA080742); DOV was supported by NIH (R01-CA112523 and R01-CA87538); HAW was supported by NIH (R01-CA58598, N01-CN-55424 and N01-PC-67001); HOP was supported by Department of Defense (DOD): DAMD17-02-1-0669 and NIH/NCI (K07-CA080668, R01-CA95023, P50-CA159981, and R01-CA126841); JPN was supported by Grant-in-Aid for the Third Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare; MAC and MAY were supported by NIH (R01-CA122443, P30-CA15083, P50-CA136393), Mayo Foundation, Minnesota Ovarian Cancer Alliance, and Fred C. and Katherine B; MAL was supported by NIH/NCI (R01-CA61107), Danish Cancer Society (Research Grant 94 222 52), and the Mermaid I project; NEC was supported by NIH (R01-CA54419 and P50-CA105009) and DOD (W81XWH-10-1-02802); NJO was supported by NIH/NCI (K07 CA095666, K22-CA138563, and P30-CA072720) and the Cancer Institute of New Jersey; OPL was supported by National Health and Medical Research Council (NHMRC) of Australia (APP1025142, APP1120431); USC was supported by P01CA17054, P30CA14089, R01CA61132, N01PC67010, R03CA113148, R03CA115195, N01CN025403, and California Cancer Research Program (00-01389V-20170, 2II0200).